Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba.
Steroids
; 78(14): 1353-8, 2013 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-24161529
ABSTRACT
Four new polyhydroxylated sterols, named halicrasterols A-D (1-4), together with six known analogs (5-10) were isolated from the marine sponge Haliclona crassiloba. Compounds 1 and 2 represented rare examples of steroids featuring 17(20)E-double bonds. The structures of 1-10 were elucidated by spectroscopic analysis and comparison with reported data. This is the first report of a steroid profile for this species. The antimicrobial activities of 1-10 were evaluated against a panel of bacterial and fungal strains in vitro, and compounds 4 and 9 showed moderate activity against some of the Gram-positive strains with MICs ranging from 4 to 32 µg/mL.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esteróis
/
Haliclona
/
Anti-Infecciosos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article