Conformational studies of chemotactic HCO-Met-Leu-Phe-OMe analogues.
Amino Acids
; 9(4): 375-83, 1995 Dec.
Article
em En
| MEDLINE
| ID: mdl-24178885
ABSTRACT
In order to investigate the proper peptide backbone conformation able to elicit a biological activity, HCO-Met-Pro-Phe-OMe, HCO-Met-Ψ[COO]Leu-Phe-OMe, and HCO-Met-OLeu-Phe-OMe, analogues of the prototypical chemotactic peptide HCO-Met-Leu-Phe-OMe, were studied by CD and IR techniques. The results obtained comparing biological and conformational data evidence the critical presence of (i) the NH group at position 2, (ii) a rather flexible backbone, (iii) the chemical structure of the central residue which can affect the stability of a possible active conformer.
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MEDLINE
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En
Ano de publicação:
1995
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Article