Androgens regulate prostate cancer cell growth via an AMPK-PGC-1&#945;-mediated metabolic switch.

Tennakoon, J B; Shi, Y; Han, J J; Tsouko, E; White, M A; Burns, A R; Zhang, A; Xia, X; Ilkayeva, O R; Xin, L; Ittmann, M M; Rick, F G; Schally, A V; Frigo, D E

Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch.

Tennakoon, J B; Shi, Y; Han, J J; Tsouko, E; White, M A; Burns, A R; Zhang, A; Xia, X; Ilkayeva, O R; Xin, L; Ittmann, M M; Rick, F G; Schally, A V; Frigo, D E.

Afiliação

Tennakoon JB; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.
Shi Y; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.
Han JJ; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.
Tsouko E; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.
White MA; Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.
Burns AR; College of Optometry, University of Houston, Houston, TX, USA.
Zhang A; Center for Genomic Medicine, Houston Methodist Research Institute, Houston, TX, USA.
Xia X; Center for Genomic Medicine, Houston Methodist Research Institute, Houston, TX, USA.
Ilkayeva OR; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA.
Xin L; 1] Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA [2] Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA [3] Dan L. Duncan Cancer Center, Houston, TX, USA.
Ittmann MM; 1] Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA [2] Dan L. Duncan Cancer Center, Houston, TX, USA [3] Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, USA.
Rick FG; 1] Veterans Affairs Medical Center and South Florida VA Foundation for Research and Education, Miami, FL, USA [2] Department of Urology, Florida International University, Herbert Wertheim College of Medicine, Miami, FL, USA.
Schally AV; 1] Veterans Affairs Medical Center and South Florida VA Foundation for Research and Education, Miami, FL, USA [2] Department of Pathology, University of Miami, Miller School of Medicine, Miami, FL, USA [3] Divisions of Hematology/Oncology, University of Miami, Miller School of Medicine, Miami, FL, U
Frigo DE; 1] Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA [2] Center for Genomic Medicine, Houston Methodist Research Institute, Houston, TX, USA.

Oncogene ; 33(45): 5251-61, 2014 Nov 06.

Article em En | MEDLINE | ID: mdl-24186207

Assuntos

Proteínas Quinases Ativadas por AMP/metabolismo; Androgênios/farmacologia; Proliferação de Células/efeitos dos fármacos; Neoplasias da Próstata/metabolismo; Fatores de Transcrição/metabolismo; Proteínas Quinases Ativadas por AMP/genética; Animais; Western Blotting; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Sobrevivência Celular/genética; Glicólise/efeitos dos fármacos; Humanos; Estimativa de Kaplan-Meier; Masculino; Metribolona/farmacologia; Camundongos Knockout; Camundongos Transgênicos; Microscopia Eletrônica de Transmissão; Microscopia de Fluorescência; Mitocôndrias/genética; Mitocôndrias/metabolismo; Mitocôndrias/ultraestrutura; Fosforilação Oxidativa/efeitos dos fármacos; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo; Neoplasias da Próstata/genética; Neoplasias da Próstata/patologia; Interferência de RNA; Ratos Wistar; Receptores Androgênicos/genética; Receptores Androgênicos/metabolismo; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética; Fatores de Transcrição/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Fatores de Transcrição / Proliferação de Células / Proteínas Quinases Ativadas por AMP / Androgênios Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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