Bioactive eudesmane and germacrane derivatives from Inula wissmanniana Hand.-Mazz.
Phytochemistry
; 96: 214-22, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24189347
ABSTRACT
Phytochemical investigation of Inula wissmanniana Hand.-Mazz. afforded 21 eudesmane and germacrane derivatives, including rare 4,5-secoeudesman-12,5-olide, eudesman-12,5-olide, 3,4-secoeudesman-12-oic acid, and germacra-4-en-12,6-olides. Their structures were elucidated by combinative analyses of MS, NMR, electronic circular dichroism, and X-ray crystallography data. Moreover, most of the isolates exhibited inhibition against lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages and cytotoxicity in HepG2, PC-3, and MGC-803 tumor cells.
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Base de dados:
MEDLINE
Assunto principal:
Inula
/
Sesquiterpenos de Eudesmano
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Sesquiterpenos de Germacrano
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Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article