Synaptic metaplasticity underlies tetanic potentiation in Lymnaea: a novel paradigm.
PLoS One
; 8(10): e78056, 2013.
Article
em En
| MEDLINE
| ID: mdl-24205089
ABSTRACT
We present a mathematical model that explains and interprets a novel form of short-term potentiation, which was found to be use-, but not time-dependent, in experiments done on Lymnaea neurons. The high degree of potentiation is explained using a model of synaptic metaplasticity, while the use-dependence (which is critically reliant on the presence of kinase in the experiment) is explained using a model of a stochastic and bistable biological switch.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lymnaea
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Modelos Teóricos
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Plasticidade Neuronal
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Neurônios
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article