Vanishing bile duct syndrome after allogeneic bone marrow transplantation: is it the end of the road?
Turk J Gastroenterol
; 24(4): 359-62, 2013.
Article
em En
| MEDLINE
| ID: mdl-24254270
ABSTRACT
In this paper, we report the case of a 19-year-old male patient who presented with lymphoblastic phase of chronic myeloid leukemia and received an allogeneic bone marrow transplant from his cousin. The patient experienced severe, steroid-refractory acute graft versus-host disease of skin, gastrointestinal tract and liver that required further immunosuppression. However, hepatic graft-versus-host disease was complicated with vanishing bile duct syndrome, characterized by progressive destruction of small intrahepatic bile ducts, which was refractory to all available therapies and eventually led to end-stage liver disease. The pathogenesis and treatment of graft-versus-host disease after allogeneic hematopoietic cell transplantation is discussed with an emphasis on liver transplantation for intractable hepatic graft-versus-host disease.
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Base de dados:
MEDLINE
Assunto principal:
Doenças dos Ductos Biliares
/
Ductos Biliares Intra-Hepáticos
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Doença Enxerto-Hospedeiro
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article