ISG15 is counteracted by vaccinia virus E3 protein and controls the proinflammatory response against viral infection.
J Virol
; 88(4): 2312-8, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24257616
ABSTRACT
Conjugation of ISG15 inhibits replication of several viruses. Here, using an expression system for assaying human and mouse ISG15 conjugations (ISGylations), we have demonstrated that vaccinia virus E3 protein binds and antagonizes human and mouse ISG15 modification. To study ISGylation importance in poxvirus infection, we used a mouse model that expresses deconjugating proteases. Our results indicate that ISGylation restricts in vitro replication of the vaccinia virus VVΔE3L mutant but unconjugated ISG15 is crucial to counteract the inflammatory response produced after VVΔE3L infection.
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1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
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Replicação Viral
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Ubiquitinas
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Citocinas
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Proteínas de Ligação a RNA
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Infecções por Poxviridae
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article