Male circumcision and Mycoplasma genitalium infection in female partners: a randomised trial in Rakai, Uganda.
Sex Transm Infect
; 90(2): 150-4, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24259189
ABSTRACT
OBJECTIVE:
Previous randomised trial data have demonstrated that male circumcision reduces Mycoplasma genitalium prevalence in men. We assessed whether male circumcision also reduces M genitalium infection in female partners of circumcised men.METHODS:
HIV-negative men were enrolled and randomised to either male circumcision or control. Female partners of male trial participants from the intervention (n=437) and control (n=394) arms provided interview information and self-collected vaginal swabs that were tested for M genitalium by APTIMA transcription-mediated amplification-based assay. Prevalence risk ratios (PRR) and 95% CI of M genitalium prevalence in intervention versus control group were estimated using Poisson regression. Analysis was by intention-to-treat. An as-treated analysis was conducted to account for study-group crossovers.RESULTS:
Male and female partner enrolment sociodemographic characteristics, sexual behaviours, and symptoms of sexually transmitted infections were similar between study arms. Female M genitalium prevalence at year 2 was 3.2% (14/437) in the intervention arm and 3.6% (14/394) in the control arm (PRR=0.90, 95% CI 0.43 to 1.89, p=0.78). In an as-treated analysis, the prevalence of M genitalium was 3.4% in female partners of circumcised men and 3.3% in female partners of uncircumcised men (PRR=1.01, 95% CI 0.48 to 2.12, p=0.97).CONCLUSIONS:
Contrary to findings in men, male circumcision did not affect M genitalium infection in female partners.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Vagina
/
Parceiros Sexuais
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Infecções por HIV
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Circuncisão Masculina
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Mycoplasma genitalium
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Infecções por Mycoplasma
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article