Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis.
Mult Scler
; 19(14): 1938-42, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24277735
ABSTRACT
Emerging evidence underlines the importance of micro(mi)RNAs in the pathogenesis of multiple sclerosis (MS). Free-circulating miRNAs were investigated in serum from MS patients compared to controls. Statistically significant decreased levels of miR-15b, miR-23a and miR-223 were observed in MS patients (p < 0.05). Results were validated and replicated in two further independent MS populations. A direct correlation between miRNA levels and the EDSS score was determined in PPMS (p < 0.007). The generalized trend toward miRNA down-regulation could result in over-expression of target genes involved in disease pathogenesis. Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers.
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Base de dados:
MEDLINE
Assunto principal:
Esclerose Múltipla Crônica Progressiva
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Esclerose Múltipla Recidivante-Remitente
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MicroRNAs
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article