Gastrointestinal HCO3- transport and epithelial protection in the gut: new techniques, transport pathways and regulatory pathways.
Curr Opin Pharmacol
; 13(6): 900-8, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24280619
ABSTRACT
The concept of a protective alkaline gastric and duodenal mucus layer is a century old, yet it is amazing how much new information on HCO3(-) transport pathways has emerged recently, made possible by the extensive utilization of gene-deleted and transgenic mice and novel techniques to study HCO3(-) transport. This review highlights recent findings regarding the importance of HCO3(-) for mucosal protection of duodenum and other gastrointestinal epithelia against luminal acid and other damaging factors. Recently, methods have been developed to visualize HCO3(-) transport in vivo by assessing the surface pH in the mucus layer, as well as the epithelial pH. New information about HCO3(-) transport pathways, and emerging concepts about the intricate regulatory network that governs duodenal HCO3(-) secretion are described, and new perspectives for drug therapy discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bicarbonatos
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Transporte Biológico
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Trato Gastrointestinal
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Mucosa Intestinal
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article