Spectral detection of sickle cell anemia and thalassemia.
Photodiagnosis Photodyn Ther
; 10(4): 429-33, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24284096
ABSTRACT
Sickle cell disease (SCD) and thalassemia (Thal) are the most common inherited, autosomal, recessive blood disorders which lead to complications such as vasoocclusion and splenomegaly. Patients who suffer from these diseases have poor quality of life and shorter life span. The most common techniques for detection of these diseases are complete blood cell count, followed by electrophoresis and high performance liquid chromatography. In this connection, the results of this paper indicate the potential of a new technique, based on spectral analysis of blood plasma and cellular components, to detect SCD and Thal with accuracy of 90% and above. To the best of our knowledge this would be the first report on spectral pathology of hemoglobinopathy.
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Base de dados:
MEDLINE
Assunto principal:
Porfirinas
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Espectrometria de Fluorescência
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Talassemia
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Bilirrubina
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Biliverdina
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Anemia Falciforme
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article