One-pot peptide ligation-desulfurization at glutamate.
Org Lett
; 16(1): 290-3, 2014 Jan 03.
Article
em En
| MEDLINE
| ID: mdl-24294973
ABSTRACT
An efficient methodology for ligation at glutamate (Glu) is described. A γ-thiol-Glu building block was accessed in only three steps from protected glutamic acid and could be incorporated at the N-terminus of peptides. The application of these peptides in one-pot ligation-desulfurization chemistry is demonstrated with a range of peptide thioesters, and the utility of this methodology is highlighted through the synthesis of the osteoporosis peptide drug teriparatide (Forteo).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Ácido Glutâmico
/
Teriparatida
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article