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Autonomic function is not associated with the incidence of type 2 diabetes in a high-risk population: the Hoorn study.
Hillebrand, S; de Mutsert, R; den Heijer, M; le Cessie, S; Stehouwer, C D A; Nijpels, G; Dekker, J M.
Afiliação
  • Hillebrand S; Leiden University Medical Centre, Department of Clinical Epidemiology, C7-112, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands. Electronic address: s.hillebrand@lumc.nl.
  • de Mutsert R; Leiden University Medical Centre, Department of Clinical Epidemiology, C7-112, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands.
  • den Heijer M; Leiden University Medical Centre, Department of Clinical Epidemiology, C7-112, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands; Department of Endocrinology, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
  • le Cessie S; Leiden University Medical Centre, Department of Clinical Epidemiology, C7-112, Albinusdreef 2, PO Box 9600, 2300 RC Leiden, The Netherlands.
  • Stehouwer CD; Department of Internal Medicine, Endocrinology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
  • Nijpels G; Department of General Practice, EMGO Institute VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
  • Dekker JM; Department of Epidemiology and Biostatistics, EMGO Institute VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
Diabetes Metab ; 40(2): 128-36, 2014 Apr.
Article em En | MEDLINE | ID: mdl-24308949
AIM: Impaired autonomic function is a complication of type 2 diabetes mellitus (DM2), but may also be involved in its development. For this reason, this study looked at the association of autonomic function with the incidence of DM2 in a homogeneous Caucasian population. METHODS: This Hoorn study was a prospective population-based study of individuals aged 50-75 years. For the 631 participants, the standard deviation of all normal-to-normal intervals (SDNN) and eight other parameters of autonomic function were calculated at baseline. Fasting and 2-h glucose were measured during follow-up by oral glucose tolerance test (OGTT). DM2 at baseline and follow-up was ascertained by questionnaire and OGTT. After excluding participants with DM2 at baseline, the association of parameters of autonomic function with incident diabetes was examined using logistic-regression analysis while adjusting for possible confounders. RESULTS: After excluding those with known (n=67) or newly diagnosed (n=126) DM2 at baseline and those missing follow-up data (n=140), 298 participants were eligible for the study (182 with normal glucose tolerance, 19 with impaired fasting glucose and 97 with impaired glucose tolerance). During a median follow-up of 9.2 (range 4.5-11.1) years, 94 incident cases of DM2 were observed. After adjusting for confounding variables, the DM2 odds ratio was 1.12 (95% CI: 0.77, 1.64) per SDNN increase. Results for other parameters of autonomic function were similar. CONCLUSION: The present study found no evidence of an association between autonomic function and DM2 incidence in a population at high risk of diabetes. This implies that previously observed associations between autonomic function and glucose metabolism in cross-sectional settings may reflect reverse causation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças do Sistema Nervoso Autônomo / Glicemia / Complicações do Diabetes / Diabetes Mellitus Tipo 2 Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças do Sistema Nervoso Autônomo / Glicemia / Complicações do Diabetes / Diabetes Mellitus Tipo 2 Idioma: En Ano de publicação: 2014 Tipo de documento: Article