Liquid chromatography-tandem mass spectrometry assay for therapeutic drug monitoring of the tyrosine kinase inhibitor, midostaurin, in plasma from patients with advanced systemic mastocytosis.

Bourget, Philippe; Amin, Alexandre; Chandesris, Marie-Olivia; Vidal, Fabrice; Merlette, Christophe; Hirsch, Isabelle; Cabaret, Laure; Carvalhosa, Ana; Mogenet, Agnès; Frenzel, Laurent; Damaj, Gandhi; Lortholary, Olivier; Hermine, Olivier

Bourget, Philippe; Amin, Alexandre; Chandesris, Marie-Olivia; Vidal, Fabrice; Merlette, Christophe; Hirsch, Isabelle; Cabaret, Laure; Carvalhosa, Ana; Mogenet, Agnès; Frenzel, Laurent; Damaj, Gandhi; Lortholary, Olivier; Hermine, Olivier.

Afiliação

Bourget P; Clinical Pharmacy, Necker Hospital, 149 rue de Sèvres, Paris 75015, France. Electronic address: philippe.bourget@nck.aphp.fr.
Amin A; Clinical Pharmacy, Necker Hospital, 149 rue de Sèvres, Paris 75015, France. Electronic address: alexandre.amin@nck.aphp.fr.
Chandesris MO; Hematology Department, Necker Hospital, 149 rue de Sèvres, Paris 75015, France; Centre de référence des mastocytoses (CEREMAST), Necker Hospital, 149 rue de Sèvres, Paris 75015, France.
Vidal F; Clinical Pharmacy, Necker Hospital, 149 rue de Sèvres, Paris 75015, France.
Merlette C; Clinical Pharmacy, Necker Hospital, 149 rue de Sèvres, Paris 75015, France.
Hirsch I; Centre de référence des mastocytoses (CEREMAST), Necker Hospital, 149 rue de Sèvres, Paris 75015, France.
Cabaret L; Centre de référence des mastocytoses (CEREMAST), Necker Hospital, 149 rue de Sèvres, Paris 75015, France.
Carvalhosa A; Hematology Department, Necker Hospital, 149 rue de Sèvres, Paris 75015, France.
Mogenet A; Clinical Investigation Department (CIC), Necker Hospital, 149 rue de Sèvres, Paris 75015, France.
Frenzel L; Hematology Department, Necker Hospital, 149 rue de Sèvres, Paris 75015, France.
Damaj G; Centre de référence des mastocytoses (CEREMAST), Necker Hospital, 149 rue de Sèvres, Paris 75015, France; Hematology Department, Amiens University Hospital, Place Victor Pauchet, Amiens 80054, France.
Lortholary O; Centre de référence des mastocytoses (CEREMAST), Necker Hospital, 149 rue de Sèvres, Paris 75015, France; Infectious Diseases Department (SMIT), Necker Hospital, 149 rue de Sèvres, Paris 75015, France.
Hermine O; Hematology Department, Necker Hospital, 149 rue de Sèvres, Paris 75015, France; Centre de référence des mastocytoses (CEREMAST), Necker Hospital, 149 rue de Sèvres, Paris 75015, France; CNRS UMR 8147, University Paris V, 15 rue de l'école de médecine, Paris 75006, France.

J Chromatogr B Analyt Technol Biomed Life Sci ; 944: 175-81, 2014 Jan 01.

Article em En | MEDLINE | ID: mdl-24316764

Assuntos

Cromatografia Líquida/métodos; Monitoramento de Medicamentos/métodos; Mastocitose Sistêmica/tratamento farmacológico; Estaurosporina/análogos & derivados; Estabilidade de Medicamentos; Humanos; Modelos Lineares; Reprodutibilidade dos Testes; Sensibilidade e Especificidade; Estaurosporina/sangue; Estaurosporina/química; Espectrometria de Massas em Tandem/métodos

Palavras-chave

AHNMD; ANSM; ASM; Advanced systemic mastocytosis; Agence Nationale de Sécurité du Médicament et des produits de santé; CEREMAST; Centre de Référence des Mastocytoses; DMSO; HESI; Human plasma; IS; Internal Standard; LCMS/MS; LLQ; MCL; Midostaurin; QC; RSD; Relative Standard Deviation; SM; SRM; TDM; TKI; TUA; Therapeutic drug monitoring; VEGFR; aggressive systemic mastocytosis; associated clonal hematological non-mast cell lineage disease; dimethylsulfoxide; heated electrospray ionization; lower limit of quantiï¬cation; mast cell leukemia; quality control; selected reaction monitoring; systemic mastocytosis; temporary use authorization; therapeutic drug monitoring; tyrosine kinase inhibitor; vascular endothelial growth factor receptor

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Monitoramento de Medicamentos / Estaurosporina / Mastocitose Sistêmica Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google