Post-transplantation consolidation and maintenance therapy with lenalidomide for Japanese patients with multiple myeloma.
Anticancer Res
; 33(12): 5681-5, 2013 Dec.
Article
em En
| MEDLINE
| ID: mdl-24324117
ABSTRACT
BACKGROUND:
Post-autologous stem cell transplantation (ASCT) consolidation and maintenance therapies in multiple myeloma (MM) have recently been the central focus of studies. However, there have been no reports of Japanese patients with MM treated with post-ASCT consolidation/maintenance therapies. PATIENTS ANDMETHODS:
We retrospectively evaluated eight Japanese patients with newly-diagnosed symptomatic MM who received ASCT after high-dose melphalan, and three to four courses of bortezomib-plus-dexamethasone and two courses of lenalidomide-plus-dexamethasone followed by maintenance lenalidomide for 6-24 months.RESULTS:
Four patients achieved complete response (CR) after ASCT, and five patients (63%) achieved stringent CR after the consolidation and maintenance therapy; two out of these five were in molecular CR. At the median follow-up of 38 months, all patients were alive and only one patient had disease progression following post-ASCT therapy.CONCLUSION:
Post-ASCT consolidation and maintenance therapy using lenalidomide may be effective in the treatment of Japanese patients with MM.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Talidomida
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Transplante de Células-Tronco Hematopoéticas
/
Mieloma Múltiplo
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article