Efficacy of simethicone and N-acetylcysteine as premedication in improving visibility during upper endoscopy.
J Gastroenterol Hepatol
; 29(4): 769-74, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24325147
ABSTRACT
BACKGROUND:
Simethicone and N-acetylcysteine have been widely used in improving endoscopic visibility. However, the optimal dose, volume, and dosing time for the premedication regimen are still unclear.AIM:
Our aim was to assess the efficacy of premedication in improving endoscopic visibility and determine the contributions of dose, volume, and premedication time.METHODS:
A total of 1849 patients were prospectively treated in three groups group A 100-mg simethicone suspension in 5 mL water; group B 100-mg simethicone suspension in 100 mL water; and group C 100-mg simethicone suspension in 100 mL water containing 200 mg N-acetylcysteine. Mucosa visibility was assessed at seven sites of upper gastrointestinal tract. The sum of scores was considered as total mucosal visibility score (TMVS).RESULTS:
The upper body of stomach had the worst visibility score for all groups. TMVS of groups B and C were significantly lower than those of group A. Group C had a significantly fewer patients requiring endoscopic flushing than groups A and B. The TMVS for groups B and C were significantly lower than for group A within 30 min of beginning premedication. Beyond 30 min of premedication, there was no significant difference in the TMVS among groups.CONCLUSIONS:
Premedication using 100 mg simethicone in 100 mL of water improves endoscopic visibility. Addition of N-acetylcysteine to simethicone in 100 mL of water reduces the need for endoscopic flushing. For patients unable to tolerate a large fluid volume, a 5-mL simethicone suspension administered more than 30 min prior to upper endoscopy is suggested.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Pré-Medicação
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Acetilcisteína
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Simeticone
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Aumento da Imagem
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Endoscopia do Sistema Digestório
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article