Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats.
Biomark Med
; 8(1): 85-94, 2014.
Article
em En
| MEDLINE
| ID: mdl-24325231
ABSTRACT
AIMS:
To determine whether urinary biomarkers of acute kidney injury can be used to monitor the progression of chronic kidney injury in a rat model of hypertension and obesity. MATERIALS &METHODS:
A suite of novel urinary biomarkers were used to track the progression of kidney damage in SHROB and SHR-lean rats.RESULTS:
Urinary albumin, NAG, clusterin, osteopontin, RPA-1 and fibrinogen levels were significantly elevated over time and were closely associated with the severity of histopathologically determined nephropathy in both SHROB and SHR-lean rats.CONCLUSION:
Urinary biomarkers, such as albumin, fibrinogen, NAG, clusterin, RPA-1 and osteopontin, may serve as useful tools to track the progression of chronic kidney disease associated with hypertension and obesity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
/
Insuficiência Renal Crônica
/
Hipertensão
/
Obesidade
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article