Whole blood cells loaded with messenger RNA as an anti-tumor vaccine.
Adv Healthc Mater
; 3(6): 837-42, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24339387
ABSTRACT
The use of a cell-based vaccine composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti-tumor immunity comparable to DC-RNA immunization. This approach offers a simple and affordable alternative to RNA-based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC-based immunizations.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Sanguíneas
/
RNA Mensageiro
/
Vacinas Anticâncer
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article