[Plasma lipid spectrum and survival in rats with heart failure varied by severity under the influence of neurohormonal modulators].
Patol Fiziol Eksp Ter
; (3): 51-4, 2013.
Article
em Ru
| MEDLINE
| ID: mdl-24340620
ABSTRACT
In rats with relatively mild chronic heart failure (CHF) there was an increase in plasma LDL levels. In turn, in severe CHF it was revealed a significant decrease in total cholesterol concentration due to LDL levels decline. ACE inhibitors (captopril, enalapril and lisinopril) and the most selective beta1-adrenoblockers (metoprolol, nebivolol) had not any significant influence on plasma lipids. Less selective and especially nonselective beta-adrenoblockers pindolol and propranolol brought up the atherogenic potential of plasma because of HDL levels reduction in mild CHF whereas in case of severe model--due to the trends toward decrease in HDL concentration and toward increase in LDL levels. Lipophilic ACE-inhibitors and beta-adrenoblockers without intrinsic sympathomimetic activity improved survival in rats with mild CHF to the equal extent. On the contrary in severe CHF beta-adrenoblockers, especially non-selective, had an advantage over ACE inhibitors on the survival effect.
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Base de dados:
MEDLINE
Assunto principal:
Antagonistas Adrenérgicos beta
/
Insuficiência Cardíaca
/
Lipoproteínas LDL
Idioma:
Ru
Ano de publicação:
2013
Tipo de documento:
Article