In vitro models of the metastatic cascade: from local invasion to extravasation.
Drug Discov Today
; 19(6): 735-42, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24361339
ABSTRACT
A crucial event in the metastatic cascade is the extravasation of circulating cancer cells from blood capillaries to the surrounding tissues. The past 5 years have been characterized by a significant evolution in the development of in vitro extravasation models, which moved from traditional transmigration chambers to more sophisticated microfluidic devices, enabling the study of complex cell-cell and cell-matrix interactions in multicellular, controlled environments. These advanced assays could be applied to screen easily and rapidly a broad spectrum of molecules inhibiting cancer cell endothelial adhesion and extravasation, thus contributing to the design of more focused in vivo tests.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Técnicas Analíticas Microfluídicas
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Células Neoplásicas Circulantes
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Invasividade Neoplásica
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article