Hexachlorobenzene and pentachlorobenzene accumulation, metabolism and effect on steroid secretion and on CYP11A1 and CYP19 expression in cultured human placental tissue.

Gregoraszczuk, E L; Ptak, A; Karpeta, A; Fiedor, E; Wróbel, A; Milewicz, T; Falandysz, J

Gregoraszczuk, E L; Ptak, A; Karpeta, A; Fiedor, E; Wróbel, A; Milewicz, T; Falandysz, J.

Afiliação

Gregoraszczuk EL; Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University in Krakow, Gronostajowa 9, 30-387 Kraków, Poland. Electronic address: ewa.gregoraszczuk@uj.edu.pl.
Ptak A; Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University in Krakow, Gronostajowa 9, 30-387 Kraków, Poland.
Karpeta A; Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University in Krakow, Gronostajowa 9, 30-387 Kraków, Poland.
Fiedor E; Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University in Krakow, Gronostajowa 9, 30-387 Kraków, Poland.
Wróbel A; Department of Physiology and Toxicology of Reproduction, Institute of Zoology, Jagiellonian University in Krakow, Gronostajowa 9, 30-387 Kraków, Poland.
Milewicz T; Department of Gynecological Endocrinology Collegium Medicum, Jagiellonian University in Krakow, Kopernika 23, 31-501 Kraków, Poland.
Falandysz J; Research Group of Environmental Chemistry, Ecotoxicology & Food Toxicology, Institute of Environmental Sciences & Public Health, University of Gdansk, Sobieskiego 18, 80-952 Gdansk, Poland.

Reprod Toxicol ; 43: 102-10, 2014 Jan.

Article em En | MEDLINE | ID: mdl-24365113

Assuntos

Clorobenzenos/farmacologia; Hexaclorobenzeno/farmacologia; Placenta/efeitos dos fármacos; Aromatase/metabolismo; Arilsulfotransferase/metabolismo; Catecol O-Metiltransferase/metabolismo; Enzima de Clivagem da Cadeia Lateral do Colesterol/metabolismo; Citocromo P-450 CYP1A1/metabolismo; Estradiol/metabolismo; Feminino; Humanos; Placenta/metabolismo; Gravidez; Progesterona/metabolismo

Palavras-chave

Accumulation; Hexachlorobenzene; Metabolism; Pentachlorobenzene; Placenta; Steroidogenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Clorobenzenos / Hexaclorobenzeno Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Clorobenzenos / Hexaclorobenzeno Idioma: En Ano de publicação: 2014 Tipo de documento: Article