Iron status and C-reactive protein in canine leishmaniasis.
J Small Anim Pract
; 55(2): 95-101, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24372300
ABSTRACT
OBJECTIVE:
To investigate the iron status, its relationship with C-reactive protein and the prognostic value of both in canine leishmaniasis.METHOD:
Eighty-six dogs with leishmaniasis and two control groups (healthy dogs and dogs with diseases other than leishmaniasis) were selected. Iron status indicators and C-reactive protein were compared between the three groups. Correlations between C-reactive protein and iron, ferritin and total iron-binding capacity were evaluated in dogs with leishmaniasis. Iron, total iron-binding capacity and ferritin were compared between dogs stratified according to similar C-reactive protein concentrations. The mortality rate at 30 days post-diagnosis was compared between groups. Iron status indicators and C-reactive protein were compared between survivors and non-survivors.RESULTS:
Dogs with leishmaniasis had lower iron and total iron-binding capacity and higher ferritin and C-reactive protein. There was a significant but low correlation of C-reactive protein with iron, ferritin and total iron-binding capacity. Dogs with leishmaniasis had decreased iron and total iron-binding capacity and increased ferritin compared to other ill patients with similar C-reactive protein concentrations. Mortality was not significantly different between groups but non-survivor dogs with leishmaniasis had higher C-reactive protein and lower total iron-binding capacity. CLINICALSIGNIFICANCE:
Inflammation contributes to the iron status alterations found in canine leishmaniasis but other mechanisms are likely involved. Low total iron-binding capacity and increased C-reactive protein are risk factors for outcome in canine leishmaniasis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Leishmaniose
/
Doenças do Cão
/
Ferro
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article