Non-homologous end joining pathway is the major route of protection against 4ß-hydroxywithanolide E-induced DNA damage in MCF-7 cells.

You, B-J; Wu, Y-C; Lee, C-L; Lee, H-Z

You, B-J; Wu, Y-C; Lee, C-L; Lee, H-Z.

Afiliação

You BJ; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan.
Wu YC; School of Pharmacy, China Medical University, Taichung, Taiwan.
Lee CL; School of Pharmacy, China Medical University, Taichung, Taiwan.
Lee HZ; School of Pharmacy, China Medical University, Taichung, Taiwan. Electronic address: hong@mail.cmu.edu.tw.

Food Chem Toxicol ; 65: 205-12, 2014 Mar.

Article em En | MEDLINE | ID: mdl-24373828

Assuntos

Dano ao DNA; Reparo do DNA por Junção de Extremidades; Vitanolídeos/toxicidade; Humanos; Células MCF-7

Palavras-chave

4ß-Hydroxywithanolide E; ATM-dependent DNA damage; Breast cancer; Dietary chemopreventive agent; Non-homologous end joining pathway; Reactive oxygen species

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dano ao DNA / Vitanolídeos / Reparo do DNA por Junção de Extremidades Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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