Study on the interaction between 4-thio-5-methyluridine and human serum albumin by spectroscopy and molecular modeling.
Spectrochim Acta A Mol Biomol Spectrosc
; 121: 724-31, 2014.
Article
em En
| MEDLINE
| ID: mdl-24374886
ABSTRACT
The interaction between 4-thio-5-methyluridine and human serum albumin (HSA) under simulative physiological conditions has been studied by the methods of fluorescence, UV-VIS absorbance and circular dichroism (CD) spectroscopy. The results show that 4-thio-5-methyluridine has a static fluorescence quenching on human serum albumin (HSA). The main forces of both interactions have typical static interaction from thermodynamic data to the determination. The experimental result was in correspondence with molecular modeling theory.
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Base de dados:
MEDLINE
Assunto principal:
Tiouridina
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Uridina
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Albumina Sérica
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Modelos Moleculares
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article