TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-&#954;B pathways and signals TRAF2 protein degradation in macrophages.

Ruspi, Gerhard; Schmidt, Emily M; McCann, Fiona; Feldmann, Marc; Williams, Richard O; Stoop, A Allart; Dean, Jonathan L E

TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.

Ruspi, Gerhard; Schmidt, Emily M; McCann, Fiona; Feldmann, Marc; Williams, Richard O; Stoop, A Allart; Dean, Jonathan L E.

Afiliação

Ruspi G; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, Oxford OX3 7FY, United Kingdom.
Schmidt EM; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, Oxford OX3 7FY, United Kingdom.
McCann F; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, Oxford OX3 7FY, United Kingdom.
Feldmann M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, Oxford OX3 7FY, United Kingdom.
Williams RO; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, Oxford OX3 7FY, United Kingdom.
Stoop AA; Innovation Biopharm Discovery Unit, Biopharm R&D, GlaxoSmithKline, Cambridge CB4 0WG, United Kingdom.
Dean JL; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, Oxford OX3 7FY, United Kingdom. Electronic address: jonathan.dean@kennedy.ox.ac.uk.

Cell Signal ; 26(4): 683-90, 2014 Apr.

Article em En | MEDLINE | ID: mdl-24378531

Assuntos

Macrófagos/metabolismo; NF-kappa B/metabolismo; Receptores Tipo II do Fator de Necrose Tumoral/metabolismo; Fator 2 Associado a Receptor de TNF/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo; Animais; Células Cultivadas; Ativação Enzimática/efeitos dos fármacos; Humanos; Proteínas I-kappa B/metabolismo; Ligantes; Lipopolissacarídeos/farmacologia; Macrófagos/citologia; Camundongos; Inibidor de NF-kappaB alfa; Receptores Tipo I de Fatores de Necrose Tumoral/deficiência; Receptores Tipo I de Fatores de Necrose Tumoral/genética; Receptores Tipo I de Fatores de Necrose Tumoral/metabolismo; Receptores Tipo II do Fator de Necrose Tumoral/deficiência; Receptores Tipo II do Fator de Necrose Tumoral/genética; Transdução de Sinais/efeitos dos fármacos; Fator de Necrose Tumoral alfa/farmacologia

Palavras-chave

Macrophage; TNF; TNFR; TRAF2; p55; p75

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Proteínas Quinases p38 Ativadas por Mitógeno / Fator 2 Associado a Receptor de TNF / Receptores Tipo II do Fator de Necrose Tumoral / Macrófagos Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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