Quantification of free and total desmosine and isodesmosine in human urine by liquid chromatography tandem mass spectrometry: a comparison of the surrogate-analyte and the surrogate-matrix approach for quantitation.

Ongay, Sara; Hendriks, Gert; Hermans, Jos; van den Berge, Maarten; ten Hacken, Nick H T; van de Merbel, Nico C; Bischoff, Rainer

Ongay, Sara; Hendriks, Gert; Hermans, Jos; van den Berge, Maarten; ten Hacken, Nick H T; van de Merbel, Nico C; Bischoff, Rainer.

Afiliação

Ongay S; University of Groningen, Department of Pharmacy, Analytical Biochemistry, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Hendriks G; Bioanalytical Laboratory, PRA, Early Development Services, Westerbrink 3, 9405 BJ Assen, The Netherlands.
Hermans J; University of Groningen, Department of Pharmacy, Analytical Biochemistry, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
van den Berge M; University of Groningen, University Medical Center Groningen, Department of Pulmonology, Hanzeplein 1, 9713 GZ Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
ten Hacken NH; University of Groningen, University Medical Center Groningen, Department of Pulmonology, Hanzeplein 1, 9713 GZ Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
van de Merbel NC; University of Groningen, Department of Pharmacy, Analytical Biochemistry, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands; Bioanalytical Laboratory, PRA, Early Development Services, Westerbrink 3, 9405 BJ Assen, The Netherlands.
Bischoff R; University of Groningen, Department of Pharmacy, Analytical Biochemistry, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. Electronic address: r.p.h.bischoff@rug.nl.

J Chromatogr A ; 1326: 13-9, 2014 Jan 24.

Article em En | MEDLINE | ID: mdl-24380655

Assuntos

Desmosina/urina; Isodesmosina/urina; Idoso; Biomarcadores/urina; Calibragem; Estudos de Casos e Controles; Cromatografia Líquida; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Peptídeos/urina; Doença Pulmonar Obstrutiva Crônica/urina; Espectrometria de Massas em Tandem

Palavras-chave

COPD; Desmosine; Internal standard; Surrogate analyte; Surrogate matrix; Validation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desmosina / Isodesmosina Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desmosina / Isodesmosina Idioma: En Ano de publicação: 2014 Tipo de documento: Article