Severe skin ulceration associated with Wegener's granulomatosis: successful treatment with hyperbaric oxygen and prostaglandin E1.

Abstract A 36-year-old woman patient with intractable skin ulcers associated with Wegener's granulomatosis was successfully cured by combination therapy with hyperbaric oxygenation therapy (HBO) and intravenous prostaglandin E1 (PGE1). Treatment for 4 months with prednisolone, intravenous PGE1, and cyclophosphamide did not result in healing of the multiple skin lesions on her legs. Repeated HBO with intravenous PGE1 therapy over 6 months resulted in a complete healing of the skin ulcers. We recommend the use of HBO combined with PGE1 for severe cutaneous lesions associated with generalized vasculitis.