Pain and small fiber function in Charcot-Marie-Tooth disease type 1A.
Muscle Nerve
; 50(3): 366-71, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24395492
ABSTRACT
INTRODUCTION:
Charcot-Marie-Tooth (CMT) disease type 1A is the most common form of CMT. The main clinical features are distal weakness, sensory loss, and skeletal deformities. Although pain is a frequent complaint, small fiber involvement in CMT1A has not been studied extensively.METHODS:
We assessed pain and small fiber involvement in 49 CMT1A patients using a variety of pain scales, pain questionnaires, and thermal thresholds.RESULTS:
Forty-three of 49 patients (88%) complained of pain. The pain was localized to the feet in 61% of patients. Only 18% of patients had neuropathic pain. Cold and warm detection thresholds were elevated in 53% and 12% of patients, respectively.CONCLUSIONS:
Our findings confirm that CMT1A patients have significant pain, which is more likely to be multifactorial in origin and suggests that a proportion of patients have small fiber dysfunction affecting mainly thinly myelinated Aδ fibers.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Dor
/
Doença de Charcot-Marie-Tooth
/
Fibras Nervosas
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article