Drugging a stem cell compartment using Wnt3a protein as a therapeutic.

Dhamdhere, Girija R; Fang, Mark Y; Jiang, Jie; Lee, Katherine; Cheng, Du; Olveda, Rebecca C; Liu, Bo; Mulligan, Kimberley A; Carlson, Jeffery C; Ransom, Ryan C; Weis, William I; Helms, Jill A

Dhamdhere, Girija R; Fang, Mark Y; Jiang, Jie; Lee, Katherine; Cheng, Du; Olveda, Rebecca C; Liu, Bo; Mulligan, Kimberley A; Carlson, Jeffery C; Ransom, Ryan C; Weis, William I; Helms, Jill A.

Afiliação

Dhamdhere GR; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California, United States of America.
Fang MY; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California, United States of America.
Jiang J; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California, United States of America.
Lee K; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California, United States of America.
Cheng D; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California, United States of America.
Olveda RC; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California, United States of America.
Liu B; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California, United States of America.
Mulligan KA; Department of Developmental Biology, Howard Hughes Medical Institute (HHMI), Institute for Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, California, United States of America.
Carlson JC; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California, United States of America.
Ransom RC; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California, United States of America.
Weis WI; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford School of Medicine, Stanford, California, United States of America.
Helms JA; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, California, United States of America.

PLoS One ; 9(1): e83650, 2014.

Article em En | MEDLINE | ID: mdl-24400074

Assuntos

Células-Tronco/efeitos dos fármacos; Células-Tronco/metabolismo; Proteína Wnt3A/metabolismo; Proteína Wnt3A/farmacologia; Animais; Células da Medula Óssea/efeitos dos fármacos; Células da Medula Óssea/metabolismo; Proteínas de Transporte/metabolismo; Sobrevivência Celular/efeitos dos fármacos; Ácidos Cólicos/farmacologia; Relação Dose-Resposta a Droga; Humanos; Interações Hidrofóbicas e Hidrofílicas; Lipídeos/farmacologia; Lipossomos/química; Lipossomos/metabolismo; Camundongos; Ligação Proteica; Conformação Proteica/efeitos dos fármacos; Estabilidade Proteica; Proteínas Recombinantes/química; Proteínas Recombinantes/farmacologia; Termodinâmica; Via de Sinalização Wnt/efeitos dos fármacos; Proteína Wnt3A/química

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Proteína Wnt3A Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo

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PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Proteína Wnt3A Idioma: En Ano de publicação: 2014 Tipo de documento: Article