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Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.
O'Brien, Thomas; Oeh, Jason; Xiao, Yang; Liang, Xiaorong; Vanderbilt, Alexander; Qin, Ann; Yang, Lulu; Lee, Leslie B; Ly, Justin; Cosino, Ely; LaCap, Jennifer A; Ogasawara, Annie; Williams, Simon; Nannini, Michelle; Liederer, Bianca M; Jackson, Peter; Dragovich, Peter S; Sampath, Deepak.
Afiliação
  • O'Brien T; Department of Translational Oncology, Genentech, South San Francisco, CA.
  • Oeh J; Department of Translational Oncology, Genentech, South San Francisco, CA.
  • Xiao Y; Department of Translational Oncology, Genentech, South San Francisco, CA.
  • Liang X; Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA.
  • Vanderbilt A; Department of Biomedical Imaging, Genentech, South San Francisco, CA.
  • Qin A; Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA.
  • Yang L; Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA.
  • Lee LB; Department of Translational Oncology, Genentech, South San Francisco, CA.
  • Ly J; Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA.
  • Cosino E; Department of Translational Oncology, Genentech, South San Francisco, CA.
  • LaCap JA; Department of Translational Oncology, Genentech, South San Francisco, CA.
  • Ogasawara A; Department of Biomedical Imaging, Genentech, South San Francisco, CA.
  • Williams S; Department of Biomedical Imaging, Genentech, South San Francisco, CA.
  • Nannini M; Department of Translational Oncology, Genentech, South San Francisco, CA.
  • Liederer BM; Department of Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA.
  • Jackson P; Department of Discovery Oncology, Genentech, South San Francisco, CA.
  • Dragovich PS; Department of Discovery Chemistry, Genentech, South San Francisco, CA.
  • Sampath D; Department of Translational Oncology, Genentech, South San Francisco, CA.
Neoplasia ; 15(12): 1314-29, 2013 Dec.
Article em En | MEDLINE | ID: mdl-24403854
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pentosiltransferases / Sulfonas / Protocolos de Quimioterapia Combinada Antineoplásica / Compostos Heterocíclicos com 2 Anéis Idioma: En Ano de publicação: 2013 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pentosiltransferases / Sulfonas / Protocolos de Quimioterapia Combinada Antineoplásica / Compostos Heterocíclicos com 2 Anéis Idioma: En Ano de publicação: 2013 Tipo de documento: Article