Photocrosslinkable bioadhesive based on dextran and PEG derivatives.
Mater Sci Eng C Mater Biol Appl
; 35: 300-6, 2014 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-24411381
ABSTRACT
In this study, a hybrid photopolymeric bioadhesive system consisting of urethane methacrylated dextran (Dex-U) and 3, 4-Dihydroxyphenyl-l-alanine (DOPA) modified three-arm poly (ethylene glycol) s (PEG-DOPAs) was designed. The process of photopolymerization was detected by Photo-Differential Scanning Calorimetry (Photo-DSC). The adhesion strength was evaluated by the lap shear tests. The surface tension of the solutions, burst pressures and the cytotoxicity assays were also investigated. The addition of PEG-DOPAs significantly improved the properties of Dex-U especially in the field of adhesion strength and burst pressure. And materials variation could be tailored to match the demands for tissue repair. Compared to the Dex-U systems, the maximum adhesion strength of the copolymeric system increased from 2.7±0.1 MPa to 4.0±0.6 MPa. Owing to its strong adhesion strength, rapid curing rate and good biocompatibility, such photocrosslinkable hydrogelsa could be applied to the areas of bioadhesive.
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Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
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Adesivos Teciduais
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Dextranos
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Materiais Biomiméticos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article