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Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia.
Bach, Peter; Knerr, Laurent; Fjellström, Ola; Hansson, Kenny; Mattsson, Christer; Gustafsson, David.
Afiliação
  • Bach P; Department of Medicinal Chemistry, AstraZeneca R&D, CVMD iMed, Mölndal, Pepparedsleden 1, SE-431 83 Mölndal, Sweden. Electronic address: bach@chalmers.se.
  • Knerr L; Department of Medicinal Chemistry, AstraZeneca R&D, CVMD iMed, Mölndal, Pepparedsleden 1, SE-431 83 Mölndal, Sweden. Electronic address: laurent.knerr@astrazeneca.com.
  • Fjellström O; Department of Medicinal Chemistry, AstraZeneca R&D, CVMD iMed, Mölndal, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.
  • Hansson K; Department of Bioscience, AstraZeneca R&D, CVMD iMed, Mölndal, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.
  • Mattsson C; Department of Bioscience, AstraZeneca R&D, CVMD iMed, Mölndal, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.
  • Gustafsson D; Department of Bioscience, AstraZeneca R&D, CVMD iMed, Mölndal, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.
Bioorg Med Chem Lett ; 24(3): 821-7, 2014 Feb 01.
Article em En | MEDLINE | ID: mdl-24418773
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trombina / Desenho de Fármacos / Inibidor da Proteína C Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trombina / Desenho de Fármacos / Inibidor da Proteína C Idioma: En Ano de publicação: 2014 Tipo de documento: Article