A biochemical screen for GroEL/GroES inhibitors.
Bioorg Med Chem Lett
; 24(3): 786-9, 2014 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-24418775
ABSTRACT
High-throughput screening of 700,000 small molecules has identified 235 inhibitors of the GroEL/GroES-mediated refolding cycle. Dose-response analysis of a subset of these hits revealed that 21 compounds are potent inhibitors of GroEL/GroES-mediated refolding (IC50 <10 µM). The screening results presented herein represent the first steps in a broader aim of developing molecular probes to study chaperonin biochemistry and physiology.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Chaperonina 60
/
Chaperonina 10
/
Bibliotecas de Moléculas Pequenas
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article