L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum.
Sci Rep
; 4: 3730, 2014 Jan 16.
Article
em En
| MEDLINE
| ID: mdl-24429495
ABSTRACT
L-dopa remains the mainstay treatment for Parkinson's disease (PD), although in later stages, treatment is complicated by L-dopa-induced dyskinesias (LID). Current evidence links LID to excessive striatal L-dopa-derived dopamine (DA) release, while the possibility of a direct involvement of L-dopa itself in LID has been largely ignored. Here we show that L-dopa can alter basal ganglia activity and produce LID without enhancing striatal DA release in parkinsonian non-human primates. These data may have therapeutic implications for the management of advanced PD since they suggest that LID could result from diverse mechanisms of action of L-dopa.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dopaminérgicos
/
Levodopa
/
Discinesias
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article