Therapeutic effect of anti-αv integrin mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease.
J Neuroimmunol
; 268(1-2): 25-34, 2014 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-24434077
ABSTRACT
We examined the regulatory role of αv integrins in the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), a model of multiple sclerosis (MS). Blockade of αv integrins by anti-αv integrin monoclonal antibody (mAb) in the effector phase significantly suppressed the development of TMEV-IDD both clinically and histologically. The number of infiltrating mononuclear cells (MNCs) in the CNS was significantly decreased in mice treated with anti-αv integrin mAb. Flow cytometric analysis of cytokine staining revealed that absolute numbers of IFN-γ- and IL-17-producing CD4+ and IFN-γ-producing CD8+ T cells were significantly decreased in the CNS of mice treated with anti-αv integrin mAb. These data suggest that αv integrins may play important roles in the development of TMEV-IDD.
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Base de dados:
MEDLINE
Assunto principal:
Infecções por Cardiovirus
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Doenças Autoimunes Desmielinizantes do Sistema Nervoso Central
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Integrina alfaV
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Anticorpos Monoclonais
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article