A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013.
Euro Surveill
; 19(1)2014 Jan 09.
Article
em En
| MEDLINE
| ID: mdl-24434172
ABSTRACT
Six influenza A(H1N1)pdm09 viruses were detected in Sapporo, Japan, between November and December 2013. All six viruses possessed an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir. No epidemiological link among the six cases could be identified; none of them had received neuraminidase inhibitors before specimen collection. The haemagglutinin and neuraminidase genes of the six viruses were closely related to one another, suggesting clonal spread of a single resistant virus.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Ciclopentanos
/
Influenza Humana
/
Vírus da Influenza A Subtipo H1N1
/
Oseltamivir
/
Guanidinas
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article