Long-term efficacy and safety of alemtuzumab in advanced primary cutaneous T-cell lymphomas.
Br J Dermatol
; 170(3): 720-4, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24438061
ABSTRACT
BACKGROUND:
Alemtuzumab has been proposed as salvage therapy for refractory cutaneous T-cell lymphomas (CTCLs). Long-term follow-up data are scarce.OBJECTIVES:
To assess the efficacy and safety of alemtuzumab in the treatment of advanced CTCL.METHODS:
A multicentre retrospective analysis was carried out of 39 patients with advanced CTCL treated with alemtuzumab between 2003 and 2013.RESULTS:
Thirty-nine patients (median age 62 years, range 20-83) with Sézary syndrome (SS, n = 23) or advanced mycosis fungoides (MF, n = 16) received alemtuzumab 30 mg two to three times per week for a median duration of 12 weeks (range 1-35). Fifteen patients received maintenance therapy for a median duration of 24 weeks (range 6-277). Eleven patients (28%) had transformed disease (MF, n = 10; SS, n = 1). After a median follow-up of 24 months (range 0.3-124), eight patients (21%) were still alive. The overall response rate was 51% in the whole study group (partial response, n = 13; complete response, n = 7); 70% in patients with SS and 25% in patients with MF (P = 0.009). The median time to progression was 3.4 months (range 0.4-42). Six patients (15%; SS, n = 5; MF, n = 1) remained progression free for > 2 years (median 56 months, range 28-117). Five patients experienced cutaneous large T-cell transformation during alemtuzumab treatment and one patient developed primary cutaneous large B-cell lymphoma. Twenty-four patients (62%) had a grade three or higher infectious adverse event and 10 (26%) a haematological toxicity, which led to treatment discontinuation in 17 cases (44%) and death in two (5%).CONCLUSIONS:
Alemtuzumab may induce long-term remission in SS but seems ineffective in MF and transformed CTCL.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Linfoma Cutâneo de Células T
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Anticorpos Monoclonais Humanizados
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Antineoplásicos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article