Oral colonization: a possible source for candidemia in low-weight neonates.
J Mycol Med
; 24(2): 81-6, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24440610
ABSTRACT
OBJECTIVE:
To check the oral colonization in neonates at high-risk and to associate these cases with candidemia. SUBJECTS ANDMETHODS:
This study was conducted in the NICU. For six months, 125 high-risk neonates were investigated for oral colonization and septicemia by yeasts. From this total, 19 neonates had yeasts on the oral mucosae and 12 neonates developed fungemia. All of the 12 neonates with fungemia were included in the amount of 19 who have presented oral colonization by yeasts.RESULTS:
There was a species concordance between the yeasts of the oral mucosae and the blood in 6 neonates (50%) among the 12 neonates with oral colonization and septicemia at the same time. The yeasts isolated in these 6 cases regarding the species concordance were Candida albicans (5 cases, 83.4%) and Candida parapsilosis (1 case, 16.6%). All of the cases involving an association were confirmed by PFGE. All of the strains of yeasts involved in oral colonization and also blood presented the same karyotype. A total of 66.6% of the patients with strains in agreement progressed to death.CONCLUSION:
The results indicate the relevance of monitoring the oral microbiota, as a possible source of fungal infection, and assisting to develop appropriate therapeutic strategy.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Candida
/
Recém-Nascido de Baixo Peso
/
Candidemia
/
Mucosa Bucal
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article