Bacteriophage lambda display systems: developments and applications.
Appl Microbiol Biotechnol
; 98(7): 2853-66, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24442507
Bacteriophage (phage) Lambda (λ) has played a key historic role in driving our understanding of molecular genetics. The lytic nature of λ and the conformation of its major capsid protein gpD in capsid assembly offer several advantages as a phage display candidate. The unique formation of the λ capsid and the potential to exploit gpD in the design of controlled phage decoration will benefit future applications of λ display where steric hindrance and avidity are of great concern. Here, we review the recent developments in phage display technologies with phage λ and explore some key applications of this technology including vaccine delivery, gene transfer, bio-detection, and bio-control.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bacteriófago lambda
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Técnicas de Visualização da Superfície Celular
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Proteínas de Membrana
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article