[Changes in lipid spectrum in rats with chronic heart failure of different severity on the background of angiotensin-converting enzyme inhibitors and beta-adrenoblockers].
Zh Evol Biokhim Fiziol
; 49(4): 272-7, 2013.
Article
em Ru
| MEDLINE
| ID: mdl-24459860
ABSTRACT
The character of lipid spectrum changes in rats with experimental heart failure of non-ischemic genesis depended on its severity. In mild heart failure there was found an increase in the low density lipoprotein levels, whereas in the severe one--a decrease of total cholesterol levels at the expense of the low density lipoproteins. The ACE inhibitors produced no significant changes in the lipid spectrum. The effect of beta-adrenoblockers was determined by their selectivity for beta1-adrenoreceptors. The most selective drugs were distinguished by the metabolically neutral activity. On the contrary, nonselective beta-adrenoblockers increased the degree of plasma atherogeneity.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores da Enzima Conversora de Angiotensina
/
Colesterol
/
Antagonistas de Receptores Adrenérgicos beta 1
/
Insuficiência Cardíaca
/
Lipoproteínas LDL
Idioma:
Ru
Ano de publicação:
2013
Tipo de documento:
Article