Macrolide use leads to clinical and radiological improvement in patients with cryptogenic organizing pneumonia.
Ann Am Thorac Soc
; 11(1): 87-91, 2014 Jan.
Article
em En
| MEDLINE
| ID: mdl-24460438
ABSTRACT
Cryptogenic organizing pneumonia is an idiopathic form of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia). Because cryptogenic organizing pneumonia is considered an inflammatory disease, it characteristically responds to the broad-spectrum antiinflammatory corticosteroids, although relapse is common on discontinued use. Additionally, long-term use of corticosteroids has many side effects. In severe cases in which corticosteroids have failed, either cytotoxic therapy or macrolide therapy is used. Because of the toxicity and adverse effects of cytotoxic therapy (e.g., cyclophosphamide), this therapy option cannot be used long term in refractory cases. Macrolide therapy has been shown to be an effective antiinflammatory agent that is relatively safe when used on a long-term basis in patients with cryptogenic organizing pneumonia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Claritromicina
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Pneumonia em Organização Criptogênica
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Macrolídeos
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Pulmão
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Antibacterianos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article