Interaction between nucleophosmin and HBV core protein increases HBV capsid assembly.
FEBS Lett
; 588(6): 851-8, 2014 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-24462683
ABSTRACT
Host factors are involved in Hepatitis B virus (HBV) genome replication and capsid formation during the viral life cycle. A host factor, nucleophosmin (B23), was found to bind to HBV core protein dimers, but its functional role has not been studied. This interaction promoted HBV capsid assembly and decreased the degree of capsid dissociation when subjected to denaturant treatments in vitro. In addition, inhibition of B23 reduced intracellular capsid formation resulting in a decrease of HBV production in HepG2.2.15 cells. These results provide important evidence that B23 acts on core capsid assembly via its interaction with HBV core dimers.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Nucleares
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Proteínas do Core Viral
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Vírus da Hepatite B
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Montagem de Vírus
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Proteínas do Capsídeo
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article