Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.

Vinchi, Francesca; Ingoglia, Giada; Chiabrando, Deborah; Mercurio, Sonia; Turco, Emilia; Silengo, Lorenzo; Altruda, Fiorella; Tolosano, Emanuela

Vinchi, Francesca; Ingoglia, Giada; Chiabrando, Deborah; Mercurio, Sonia; Turco, Emilia; Silengo, Lorenzo; Altruda, Fiorella; Tolosano, Emanuela.

Afiliação

Vinchi F; Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Ingoglia G; Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Chiabrando D; Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Mercurio S; Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Turco E; Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Silengo L; Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Altruda F; Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy.
Tolosano E; Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy. Electronic address: emanuela.tolosano@unito.it.

Gastroenterology ; 146(5): 1325-38, 2014 May.

Article em En | MEDLINE | ID: mdl-24486949

Assuntos

Sistema Enzimático do Citocromo P-450/biossíntese; Heme/metabolismo; Hepatócitos/enzimologia; Proteínas de Membrana Transportadoras/metabolismo; Receptores Virais/metabolismo; Animais; Benzo(a)pireno/farmacologia; Proteínas de Transporte de Cátions/metabolismo; Sistema Enzimático do Citocromo P-450/genética; Dexametasona/farmacologia; Indução Enzimática; Ferritinas/metabolismo; Heme/biossíntese; Heme Oxigenase-1/metabolismo; Hemólise; Hepatócitos/efeitos dos fármacos; Homeostase; Imidazóis/farmacologia; Proteínas de Membrana/metabolismo; Proteínas de Membrana Transportadoras/genética; Camundongos; Camundongos Knockout; Fenil-Hidrazinas/farmacologia; RNA Mensageiro/metabolismo; Receptores Virais/genética

Palavras-chave

ALAS1; CYP; Flvcr; Flvcr1; HO-1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Receptores Virais / Hepatócitos / Sistema Enzimático do Citocromo P-450 / Heme Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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