Knockdown of the T-box transcription factor Brachyury increases sensitivity of adenoid cystic carcinoma cells to chemotherapy and radiation in vitro: implications for a new therapeutic principle.

Kobayashi, Yosuke; Sugiura, Tsuyoshi; Imajyo, Ikumi; Shimoda, Miyuki; Ishii, Kotaro; Akimoto, Naonari; Yoshihama, Naoya; Mori, Yoshihide

Kobayashi, Yosuke; Sugiura, Tsuyoshi; Imajyo, Ikumi; Shimoda, Miyuki; Ishii, Kotaro; Akimoto, Naonari; Yoshihama, Naoya; Mori, Yoshihide.

Afiliação

Kobayashi Y; Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Sugiura T; Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Imajyo I; Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Shimoda M; Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Ishii K; Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Akimoto N; Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Yoshihama N; Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Mori Y; Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.

Int J Oncol ; 44(4): 1107-17, 2014 Apr.

Article em En | MEDLINE | ID: mdl-24504414

Assuntos

Carcinoma Adenoide Cístico/tratamento farmacológico; Carcinoma Adenoide Cístico/radioterapia; Resistencia a Medicamentos Antineoplásicos/genética; Proteínas Fetais/genética; Tolerância a Radiação/genética; Proteínas com Domínio T/genética; Transportadores de Cassetes de Ligação de ATP/biossíntese; Caderinas/genética; Carcinoma Adenoide Cístico/genética; Linhagem Celular Tumoral; Movimento Celular/genética; Quimiorradioterapia; Transição Epitelial-Mesenquimal; Regulação Neoplásica da Expressão Gênica; Humanos; Invasividade Neoplásica/genética; Metástase Neoplásica; Células-Tronco Neoplásicas/patologia; Células-Tronco Neoplásicas/efeitos da radiação; Interferência de RNA; RNA Interferente Pequeno; Proteína Carregadora de Folato Reduzido/biossíntese; Fatores de Transcrição SOXB1/genética; Vimentina/biossíntese

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tolerância a Radiação / Carcinoma Adenoide Cístico / Resistencia a Medicamentos Antineoplásicos / Proteínas com Domínio T / Proteínas Fetais Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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