Synthesis and in vivo evaluation of N-ethylamino-2-oxo-1,2-dihydro-quinoline-3-carboxamide for inhibition of intestinal tumorigenesis in APC(Min/+) mice.

Pathuri, Gopal; Li, Qian; Mohammed, Altaf; Gali, Hariprasad; Pento, J Thomas; Rao, Chinthalapally V

Pathuri, Gopal; Li, Qian; Mohammed, Altaf; Gali, Hariprasad; Pento, J Thomas; Rao, Chinthalapally V.

Afiliação

Pathuri G; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA; Hematology/Oncology Section, Department of Internal Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117,
Li Q; Hematology/Oncology Section, Department of Internal Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA; Center for Cancer Prevention and Drug Development, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA.
Mohammed A; Hematology/Oncology Section, Department of Internal Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA; Center for Cancer Prevention and Drug Development, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA.
Gali H; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA; Experimental Therapeutics Program, Peggy and Charles Stephenson Oklahoma Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73
Pento JT; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA; Experimental Therapeutics Program, Peggy and Charles Stephenson Oklahoma Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73
Rao CV; Hematology/Oncology Section, Department of Internal Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA; Center for Cancer Prevention and Drug Development, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA.

Bioorg Med Chem Lett ; 24(5): 1380-2, 2014 Mar 01.

Article em En | MEDLINE | ID: mdl-24507628

Assuntos

Amidas/química; Antineoplásicos/síntese química; Inibidores de Proteínas Quinases/síntese química; Quinolinas/química; Polipose Adenomatosa do Colo/tratamento farmacológico; Amidas/farmacologia; Amidas/uso terapêutico; Animais; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Carcinogênese/efeitos dos fármacos; Neoplasias do Colo/tratamento farmacológico; Modelos Animais de Doenças; Feminino; Humanos; Masculino; Camundongos; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico; Receptor Tipo 2 de Fator de Crescimento de Fibroblastos/antagonistas & inibidores; Receptor Tipo 2 de Fator de Crescimento de Fibroblastos/metabolismo

Palavras-chave

Chemoprevention; Colon cancer; KFGR; Polyps; Tyrosine kinase inhibitor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Inibidores de Proteínas Quinases / Amidas / Antineoplásicos Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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