[A novel human leukocyte antigen-A*33:44 allele revealed by sequence analysis].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 31(1): 85-7, 2014 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-24510571
OBJECTIVE: To analyze the sequence of a novel human leukocyte antigen (HLA)-A*33:44 allele. METHODS: A novel HLA-A allele was found by double-stranded sequencing combined with single-stranded sequencing. The frequency of the novel allele was determined by population survey. RESULTS: Genomic sequence of this novel HLA-A*33:44 allele (accession No. HQ873871) has differed from HLA-B*33:03:01 by one nucleotide in exon 4, which resulted in nt 866 Gâ A substitution, which results in an amino acid substitution from Gly(GGT) to Asp(GAT) at codon 265. This alternation is a new single nucleotide polymorphism compared with other HLA-A alleles. The frequency of this new allele is less than 0.0003 in Chinese Han population. CONCLUSION: A mutation has been found in exon 4 of the novel HLA-A*33:44 allele, which may provide more information for HLA gene study.
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MEDLINE
Assunto principal:
Antígenos HLA-A
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Povo Asiático
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article