Synthesis, receptor affinity and effect on pentylenetetrazole-induced seizure threshold of novel benzodiazepine analogues: 3-Substituted 5-(2-phenoxybenzyl)-4H-1,2,4-triazoles and 2-amino-5-(phenoxybenzyl)-1,3,4-oxadiazoles.

Mashayekh, Siavash; Rahmanipour, Narges; Mahmoodi, Behnaz; Ahmadi, Fatemeh; Motaharian, Dina; Shahhosseini, Soraya; Shafaroodi, Hamed; Banafshe, Hamid R; Shafiee, Abbas; Navidpour, Latifeh

Mashayekh, Siavash; Rahmanipour, Narges; Mahmoodi, Behnaz; Ahmadi, Fatemeh; Motaharian, Dina; Shahhosseini, Soraya; Shafaroodi, Hamed; Banafshe, Hamid R; Shafiee, Abbas; Navidpour, Latifeh.

Afiliação

Mashayekh S; Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran 14176, Iran.
Rahmanipour N; Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran 14176, Iran.
Mahmoodi B; Pharmacology and Toxicology Department, Pharmaceutical Sciences Branch and Pharmaceutical Sciences Research Center, Islamic Azad University, Tehran, Iran.
Ahmadi F; Department of Radiopharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Motaharian D; Pharmacology and Toxicology Department, Pharmaceutical Sciences Branch and Pharmaceutical Sciences Research Center, Islamic Azad University, Tehran, Iran.
Shahhosseini S; Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shafaroodi H; Pharmacology and Toxicology Department, Pharmaceutical Sciences Branch and Pharmaceutical Sciences Research Center, Islamic Azad University, Tehran, Iran.
Banafshe HR; Department of Physiology & Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Shafiee A; Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran 14176, Iran.
Navidpour L; Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran 14176, Iran; Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: navidpur@sina.tu

Bioorg Med Chem ; 22(6): 1929-37, 2014 Mar 15.

Article em En | MEDLINE | ID: mdl-24530225

Assuntos

Oxidiazóis/farmacologia; Convulsões/tratamento farmacológico; Triazóis/farmacologia; Animais; Relação Dose-Resposta a Droga; Masculino; Camundongos; Camundongos Endogâmicos; Modelos Moleculares; Estrutura Molecular; Oxidiazóis/administração & dosagem; Oxidiazóis/síntese química; Pentilenotetrazol/administração & dosagem; Receptores de GABA-A/metabolismo; Convulsões/induzido quimicamente; Relação Estrutura-Atividade; Triazóis/administração & dosagem; Triazóis/síntese química

Palavras-chave

1,2,4-Triazole; 1,3,4-Oxadiazole; Flexible benzodiazepines; PTZ-induced clonic seizure threshold; Receptor binding affinity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxidiazóis / Convulsões / Triazóis Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxidiazóis / Convulsões / Triazóis Idioma: En Ano de publicação: 2014 Tipo de documento: Article