Ischemic neurons recruit natural killer cells that accelerate brain infarction.
Proc Natl Acad Sci U S A
; 111(7): 2704-9, 2014 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-24550298
ABSTRACT
Brain ischemia and reperfusion activate the immune system. The abrupt development of brain ischemic lesions suggests that innate immune cells may shape the outcome of stroke. Natural killer (NK) cells are innate lymphocytes that can be swiftly mobilized during the earliest phases of immune responses, but their role during stroke remains unknown. Herein, we found that NK cells infiltrated the ischemic lesions of the human brain. In a mouse model of cerebral ischemia, ischemic neuron-derived fractalkine recruited NK cells, which subsequently determined the size of brain lesions in a T and B cell-independent manner. NK cell-mediated exacerbation of brain infarction occurred rapidly after ischemia via the disruption of NK cell tolerance, augmenting local inflammation and neuronal hyperactivity. Therefore, NK cells catalyzed neuronal death in the ischemic brain.
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MEDLINE
Assunto principal:
Encéfalo
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Células Matadoras Naturais
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Isquemia Encefálica
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Acidente Vascular Cerebral
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Infarto Encefálico
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Imunidade Inata
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article