3D braid scaffolds for regeneration of articular cartilage.
J Mech Behav Biomed Mater
; 34: 37-46, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24556323
ABSTRACT
Regenerating articular cartilage in vivo from cultured chondrocytes requires that the cells be cultured and implanted within a biocompatible, biodegradable scaffold. Such scaffolds must be mechanically stable; otherwise chondrocytes would not be supported and patients would experience severe pain. Here we report a new 3D braid scaffold that matches the anisotropic (gradient) mechanical properties of natural articular cartilage and is permissive to cell cultivation. To design an optimal structure, the scaffold unit cell was mathematically modeled and imported into finite element analysis. Based on this analysis, a 3D braid structure with gradient axial yarn distribution was designed and manufactured using a custom-built braiding machine. The mechanical properties of the 3D braid scaffold were evaluated and compared with simulated results, demonstrating that a multi-scale approach consisting of unit cell modeling and continuum analysis facilitates design of scaffolds that meet the requirements for mechanical compatibility with tissues.
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Base de dados:
MEDLINE
Assunto principal:
Regeneração
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Materiais Biocompatíveis
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Cartilagem Articular
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Engenharia Tecidual
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Alicerces Teciduais
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article