Antiproliferative effect of Canavalia brasiliensis lectin on B16F10 cells.
Res Vet Sci
; 96(2): 276-82, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24565003
ABSTRACT
Lectins are proteins or glycoproteins with the ability to link to carbohydrates at the cell surface in a specific and reversible manner. Studies have showed that lectins are demonstrate immunomodulatory and antitumor agents. This study aims to evaluate the effect of lectin extracted from the seeds of Canavalia brasiliensis (ConBr) on murine melanoma B16F10 cells by analyzing cell viability, apoptosis index, cell migration, production of cytokines and nitric oxide (NO). Results showed that ConBr was able to reduce cell viability and thwart apoptosis, which could be observed by decrease in cell migration. ConBr also induced NO and IL-12 synthesis. Altogether, these data demonstrate the potential of ConBr as a therapeutic agent for melanoma.
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Base de dados:
MEDLINE
Assunto principal:
Apoptose
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Canavalia
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Lectinas de Plantas
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Melanoma
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article